Smoking damages DNA permanently
Despite snuff consumption has declined in many countries, tobacco use remains the leading preventable cause of death. A new study published in the Journal of the American Heart Association, Circulation: Cardiovascular Genetics, has concluded that smoking affects the human genome as DNA methylation and e ste impact can persist even 30 years after quitting.
And it is that cigarette smoking is an important modifier of DNA methylation. Experts have discovered genes associated with smoking that contribute to the development of consumption – related diseases such as prostate cancer, stomach, liver, acute bronchitis or heart disease.
“The study concludes that even after quitting, the effects of smoking on DNA still enduring.”
The researchers analyzed blood samples from almost 16,000 participants from 16 groups included in the consortium CHARGE research on aging heart and genomic epidemiology.Including a group from the Framingham Heart Study researchers they have followed since 1971.
Compared with nonsmokers, scientists discovered that DNA methylation sites associated with smoking were associated with more than 7,000 genes, representing a third of known human genes.
After 5 years without smoking , most cases of DNA methylation returned to normal, however, some maintained even 30 years after, leaving a historical trace DNA participants.
“Our study has found conclusive evidence that smoking has a lasting impact on our molecular machinery, an impact that can last more than 30 years. The good news is that once you stop smoking, most signals DNA methylation return to normal levels (as if it had never smoked) after 5 years, which means that the body is trying to heal itself of the harmful effects of snuff consumption” says Roby Joehanes, of Harvard Medical School and co-author.